Contract length: 12 months

Compensation: $30-$35/hour

Hours: 40 hours/week

Location: On-site 5 days/week in Boston (Fenway Area)

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

Manifold Bio is looking for an organized, motivated In-Vivo Research Technician to join our pharmacology team on a one-year contract. You will work alongside experienced researchers to prepare for and execute mouse studies supporting our internal drug discovery programs. This role is deliberately structured around training and growth. We are looking for someone with excellent organizational instincts, and genuine enthusiasm for learning the rest. Dosing routes, blood collection, necropsy and tissue processing can all be taught, and we are committed to teaching them. For the right person, this contract is intended as a path toward a permanent Research Associate position.

Required Qualifications

Prepare and label tubes, cages and collection supplies ahead of each study
Set up procedure rooms for dosing days and takedowns
Hands-on experience with animal handling, including the ability to confidently scruff a mouse
Comfort working with laboratory animals in a vivarium environment
Tattoo and tail-mark mice; prepare and organize study cages
Weigh animals and record data accurately
Maintain study records in Benchling
Help maintain lab and vivarium inventories
Support necropsy and tissue collection (training provided)
Process collected samples, primarily serum
As time allows, assist with tissue weighing and lysis for downstream analysis
Strong organizational skills and attention to detail
Ability to follow written protocols and SOPs accurately
A proactive approach — someone who plans ahead rather than reacting
Genuine enthusiasm for learning new techniques, and a collaborative, team-first attitude

Preferred Qualifications

Hands-on experience with animal handling, including the ability to confidently scruff a mouse
Experience with SC, IV or PO dosing
Submental blood collection
Necropsy and tissue dissection
Tissue lysis, nucleic acid extraction or other basic bench techniques
Familiarity with Benchling or similar electronic lab notebooks

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.