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Lila Sciences

Engineer I, Research Operations, (1st shift)

Cambridge, MA USA; Alewife, Cambridge, MA; One Charles Park, Cambridge, MAUnited States
Autonomous Science Platform
POSTED 30 SEPTVERIFIED 6H AGO
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Role
40 days opentrue age
Posted 30 Sept
Payats field
$76k–101kposted
▼ −35% vs market median $135k
$76k$170k
Market p25–p75
$103k–$170k
Lila Sciences p25–p75
$90k–$142kn=3
H-1B median · Software engineering
$115k
Boston · n=216 · 365d to 6 Nov
CompanyLila Sciences →
125open roles
Opened · 30d
+0
Closed · 30d
−0
3d of snapshots · 30d window
Market
37,612open · Software engineering
Opened · 7d
+2,1036% of open
All software engineering
75,150open
All tracked boards · live 10 Nov · n=37,612
Visa
24H-1B LCAs · FY26
Median wage
$142k
LCAs FY26 · n=24 · to 2026-06-03

Your Impact at LILA

Lila Sciences’ Research Operations team executes the high-throughput laboratory workflows that power our scientific platform. We are seeking a motivated and detail-oriented Engineer I to support mammalian cell-based workflows, including electroporation, lipid nanoparticle (LNP) dosing, and chemical transfection. This is an on-site, first-shift role, with scheduled hours of either 7:00 AM to 3:00 PM or 9:00 AM to 5:00 PM based on operational needs.

In this role, you will combine hands-on cell culture with laboratory automation to deliver consistent, high-quality materials for downstream applications. You will maintain mammalian cell cultures, operate automated liquid handlers and specialized instruments, monitor cell health and quality-control results, troubleshoot issues, and perform downstream characterization. You will partner with scientists and engineers to improve workflow reliability, scalability, and traceability.

What You'll Be Building

  • Execute high-throughput automated and manual workflows, including electroporation, lipid nanoparticle (LNP) dosing, and chemical transfection.
  • Maintain and passage mammalian cell lines and primary cells using aseptic technique, including cell counting and viability assessment.
  • Prepare workflow materials and operate automated liquid handlers, electroporation instruments, and related laboratory equipment.
  • Perform downstream characterization using flow cytometry, plate reader-based assays, or imaging-based methods.
  • Monitor cell health, workflow performance, and quality-control results; troubleshoot issues and escalate as needed.
  • Maintain traceable records, provide clear handoffs, and partner with scientists and engineers to improve standard operating procedures (SOPs) and workflows.

What You'll Need to Succeed

  • Bachelor’s degree in Biology, Biotechnology, Biochemistry, Cell Biology, Bioengineering, or a related scientific or engineering field, or an equivalent combination of education and relevant laboratory experience.
  • Minimum 3 years of relevant Co-Op and industry laboratory experience.
  • Hands-on mammalian cell culture experience, including aseptic technique, routine maintenance, passaging, cell counting, and viability assessment.
  • Experience with mammalian cell transfection methods, including chemical transfection, electroporation, or related delivery technologies.
  • Strong attention to detail and ability to follow SOPs and technical instructions while maintaining accurate, complete, and traceable documentation.
  • Strong analytical and problem-solving skills, including recognizing deviations, performing initial troubleshooting, and escalating appropriately.
  • Demonstrated ability to manage multiple priorities and execute reliably in a fast-paced, high-throughput laboratory environment.
  • Strong communication and collaboration skills, with the ability to provide clear status updates and work effectively across teams.
  • Ability to work on-site during first shift, with scheduled hours of either 7:00 AM to 3:00 PM or 9:00 AM to 5:00 PM based on operational needs.

Bonus Points For

  • Experience operating electroporation platforms, such as the Lonza Nucleofector or similar systems.
  • Experience with LNP dosing or LNP-mediated delivery to mammalian cells.
  • Experience handling primary human cells, such as peripheral blood mononuclear cells (PBMCs), T cells, or stem cells.
  • Hands-on experience with flow cytometry, including sample preparation, instrument operation, or data analysis.
  • Experience with plate reader-based or imaging-based cellular assays.
  • Experience operating automated liquid handlers and associated software.
  • Experience working in a high-throughput screening or production-oriented laboratory environment.

Compensation

We offer competitive base compensation with bonus potential and generous early-stage equity. Your final offer will reflect your background, expertise, and expected impact.

U.S. Benefits. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.

Source · Lila SciencesFirst seen 2 NovOriginal ↗