Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

Tango’s labs and offices are located at 201 Brookline Avenue, in the vibrant Fenway area of Boston, Massachusetts.

Summary

The Senior Vice President (SVP), Global & US Medical Affairs is a critical enterprise leader responsible for defining, building, and executing a unified, world-class medical affairs strategy for Tango Therapeutics on a global scale. As Tango transitions from a research-stage biotech into a fully integrated commercial organization, this executive will build and scale the global and US medical infrastructure required to support the successful launch and lifecycle management of our precision synthetic lethality oral oncology medicines.

Reporting directly to the Chief Commercialization Officer (CCO) and serving as a key member of the Commercial Leadership Team, the SVP will act as the senior physician leader and strategic bridge between clinical development, regulatory affairs, and commercialization. This leader will ensure that the clinical promise of our assets is translated into robust, globally aligned scientific narratives, driving external engagement, evidence generation, and medical education to support patient access and optimize product value worldwide.

Your Role

Global & US Strategic Leadership and Cross-Functional Integration

Unified Strategy: Develop, articulate, and execute an integrated Global and US Medical Affairs strategy that aligns with overall corporate objectives, clinical development plans, and global commercial strategies
Cross-Functional Partnership: Act as a critical strategic medical partner to internal stakeholders (Clinical Development, Regulatory Affairs, Market Access, and Commercial) to ensure that the Global Medical Affairs strategy seamlessly supports early-stage asset development and transitions pipeline assets into successful commercial products
Commercial Alignment: Provide strategic medical input into global commercial plans, marketing materials, and product positioning to ensure scientific integrity and alignment with clinical realities across all target markets
Lifecycle Management: Synthesize complex clinical/scientific data and global insights from the medical community to proactively inform clinical trial design, target product profiles, and lifecycle management plans

External Engagement & Global KOL Strategy

Senior Scientific Voice: Act as the primary physician leader, company spokesperson, and external scientific representative for Tango Therapeutics in both US and international markets
KOL Development: Identify, cultivate, and maintain strong, collaborative relationships with global and regional key opinion leaders (KOLs), clinical investigators, health systems, medical societies, and academic institutions, particularly within the oncology space
Field Medical Leadership: Provide strategic direction to the US Field Medical team and guide the expansion of an international field medical strategy, ensuring deep scientific exchange, gathering of clinical insights, and support for investigator-initiated studies (IIS)

Evidence Generation, Medical Communication & Patient Focus

Evidence Generation (HEOR & RWE): Serve as the medical lead for pre-launch, launch, and post-launch evidence generation globally, and oversee strategies for real-world evidence (RWE) to support the global value proposition of Tango's portfolio
Scientific Communications: Oversee the development and execution of a strategic global publication plan, scientific communication strategy, and core global materials (e.g., congress plans), ensuring the accurate, timely, and compliant dissemination of clinical data