Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity

The Vice President, Oncology Sales will lead the design, build, and execution of a high-performing, national oncology sales organization supporting Revolution Medicines products/services to the oncology communityg. Reporting to the SVP of US Marketing & Field, the VP will be responsible for creating and scaling a best-in-class sales organization, ensuring successful product launches, and driving sustained revenue growth. This leader will combine strategic vision with operational rigor, leveraging deep oncology expertise and cross-functional collaboration to position the organization for long-term success.

Key Responsibilities:

Organizational Build & Leadership

Architect and execute the build-out of a national portfolio oncology sales organization, including hiring, onboarding, and development of regional leaders, account directors, and sales representatives.

This will include nurse educator and other field facing roles or functions including sales operations and training.

Establish organizational structure, roles, and deployment strategy aligned to brand objectives and market dynamics.

Foster a high-performance culture grounded in accountability, collaboration, innovation, and patient-centricity.

Develop leadership bench strength through coaching, succession planning, and talent development initiatives.

Strategic & Commercial Leadership

Define and execute the national sales strategy across oncology indications, ensuring alignment with corporate objectives and brand strategies.

Lead all aspects of product launch readiness and execution, including field deployment, targeting, messaging alignment, and performance tracking.

Partner with Commercial Leadership Team to shape enterprise-wide strategy, providing field insights and actionable recommendations.

Drive achievement of all revenue and performance targets, ensuring consistent delivery against quarterly and annual goals.

Sales Operations & Execution Excellence

Oversee development and execution of key commercial levers including: Forecasting and demand planning, Incentive compensation design, Territory alignment and targeting, Performance analytics and reporting, Training and capability development programs.

Ensure disciplined execution of business plans and continuous optimization based on market feedback and data insights.

Key Account & Market Engagement

Lead strategy and executive engagement for top national accounts, including major health systems, IDNs, oncology networks, and GPOs.

Oversee development and execution of strategic account plans that drive access, adoption, and long-term partnerships.

Serve as a senior external representative of the company with key stakeholders and decision-makers.

Cross-Functional Collaboration

Partner closely with Marketing, Market Access, Medical Affairs, Commercial Operations, and Training to ensure aligned execution.

Lead cross-functional initiatives to address business challenges, optimize launch performance, and enhance customer experience.

Act as the “voice of the field” to inform brand strategy, pipeline planning, and organizational priorities.

Shape clinical development planning and prioritization.

Compliance & Governance

Ensure all field activities adhere to regulatory, legal, and compliance standards.