About Us

Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.

It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic—leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

Position Title: Senior Contracts Manager

Department: Legal

Reports To: Director, Contracts & Transactions Counsel

Location: Princeton, NJ – On-site 4 days per week (Mon to Thurs)

Job Overview

Kardigan is seeking an experienced Senior Contracts Manager to lead the negotiation and management of

Clinical Trial Agreements and other clinical-related agreements in support of Kardigan’s clinical development

programs. This is a hands-on drafting and negotiation role — the primary focus is clinical contracting, with

additional responsibility for general contracting needs across the business as they arise. This role does not have

ownership of Kardigan’s contract lifecycle management (CLM) system implementation or administration, which

is led separately within the Legal team. Kardigan seeks an exceptional candidate with strong clinical contracts

experience who can collaborate cross-functionally, negotiate agreements independently, and communicate

clearly and effectively with stakeholders at all levels. Attention to detail is essential. You will join our fast-paced

legal team, reporting to our Vice President, Corporate Law and Head of Transactions, and will interface directly

with Clinical Operations, R&D, and other business stakeholders across the company.

Essential Duties and Responsibilities

Clinical Contracting (Primary Responsibility)

Independently draft, review, and negotiate Clinical Trial Agreements (US and ROW), Local Sponsor Agreements, and CRO agreements.
Draft and negotiate clinical-adjacent agreements including Data Sharing and Data Processing Agreements, Standard Contractual Clauses (GDPR), Informed Consent Forms, Early Access/Compassionate Use Program agreements, Pharmacy Agreements, Indemnification Agreements, and Letters of Authorization/POAs.
Serve as the primary contracts point of contact for Clinical Operations, working closely with the team to troubleshoot obstacles that arise during clinical trial start-up, site activation, and ongoing conduct.
Track key clinical contract obligations, milestones, renewals, and deadlines across active studies and sites.
Build and maintain effective working relationships with clinical sites, CROs, CMOs, investigators, and other external clinical stakeholders.
Stay current on clinical trial regulatory and industry requirements (e.g., GCP, ICH) as they affect contract terms.