About Definitive Healthcare:

At Definitive Healthcare, our mission is simple: to connect with the real people who make healthcare happen. With real data on real people, our customers get the Definitive picture of the Healthcare market to move their businesses and organizations forward.

We’re committed to delivering the industry’s most reliable, actionable, and differentiated insights and empowering the innovators and organizations transforming healthcare. Because when our customers succeed, healthcare improves—for everyone.

Since our founding in 2011, we’ve grown into a global company headquartered just outside Boston, Massachusetts, supporting more than 2,100 customers around the world. Along the way, we’ve built a culture centered on purposeful work, collaboration, curiosity, and meaningful impact.

We’re passionate about the work we do and the people we do it with. Through programs like Definitive Cares and our employee-led affinity groups, we create opportunities for our teams to connect and give back to the communities where we live and work.

About the Role

We are seeking a hands-on Principal MLOps Engineer & Functional Lead to architect, build, and scale our next-generation Machine Learning and Generative AI infrastructure. In this role, you will design a unified, automated, and secure AI ecosystem capable of training and deploying both traditional predictive models and advanced Generative/Agentic AI systems at enterprise scale.

As the Functional Lead, you will drive engineering excellence, establish MLOps best practices across the organization, mentor senior engineers, and translate strategic business objectives into robust, highly scalable automated pipelines.

What You’ll Do

Design, implement, and maintain scalable, robust ML pipelines and data pipelines for CI/CD, and ML model deployments.
Architect and govern the enterprise feature store and vector store infrastructure to support low-latency feature retrieval for both traditional ML and Retrieval Augmented Generation (RAG) applications.
Build and manage enterprise-grade workflow orchestration layers to schedule, monitor, and manage complex, multi-stage model training and data processing dependencies.
Be a subject matter expert for Generative AI infrastructure, building scalable frameworks to support advanced LLM applications, RAG pipelines, and multi-agent Agentic AI workflows.
Establish highly efficient environments for model training and parameter-efficient fine-tuning of open-source and proprietary models.
Optimize high-throughput, low-latency model inference pipelines, utilizing advanced caching and compute distribution techniques to handle large-scale concurrent requests.
Establish and enforce lifecycle management policies utilizing an enterprise model registry to manage version control, lineage, and tracking from experimentation to production.
Architect high-performing, cost-efficient infrastructure utilizing autoscaling groups on AWS to dynamically handle varying training and inference workloads.
Implement comprehensive, real-time endpoint monitoring systems to track model performance, data drift, latency, and system health metrics.
Serve as the functional lead for ML engineering, defining coding standards, architectural blueprints, framework selections, and operational SLAs.
Provide technical guidance, code reviews, and mentorship to senior machine learning and data engineers, fostering an agile culture of innovation, automation, and continuous improvement.

What You'll Bring

Bachelor's or Master’s degree in Computer Science, Computer Engineering, Data Science, or a closely related quantitative engineering discipline.
12+ years of professional experience in data engineering, ML engineering with a minimum of 5 years dedicated to building, scaling, and managing MLOps platforms in production.
Deep, hands-on production experience architecting with in Databricks and native Aws environments.
Expert proficiency in Python, with strong production experience deploying models built in TensorFlow and PyTorch.