Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

The Product Development Operations (PDO) Partnership Manager (Client Project Manager) will provide strategic and operational leadership for end-to-end supply chain activities supporting Arrowhead’s out-licensing collaborations and regional commercial partnerships. This role manages clinical and commercial supply for partner-territory products across a growing portfolio of partnerships (e.g., Takeda, GSK, Sarepta, Novartis, and additional current and future partners), serving as the primary supply chain liaison to ensure uninterrupted delivery of Arrowhead’s RNAi therapeutics into partner-managed markets globally.

This position plays a key role in scaling Arrowhead’s partnership operations from early clinical supply through commercial launch and lifecycle management, ensuring contractual compliance, forecast accuracy, supply continuity, and cost-effective execution while supporting global regulatory filings across multiple health authorities.

Responsibilities

Partnership Supply Chain Leadership

Serve as the primary supply chain point of accountability and liaison for Arrowhead’s partner-facing supply activities, including current partnerships such as Takeda, GSK, and Sarepta, Novartis, as well as additional current and future regional and global collaborations.
Represent Arrowhead Supply Chain in Joint Manufacturing Committees, Joint Operating Committees, and supply working group forums with each partner.
Translate partnership contracts (Supply Agreements, Quality Agreements, Clinical Supply Agreements, CSAs) into operational plans, SoWs, SOPs, and KPIs, ensuring Arrowhead meets all contractual obligations including lead times, forecast accuracy, allocation rules, and service levels.
Build and maintain trusted, transparent working relationships with counterpart supply chain, regulatory, and quality leaders at each partner organization.

Demand & Supply Planning

Support the integrated S&OP process for partner products, consolidating partner forecasts and incorporate into Arrowhead’s global supply plan and reconciling against drug substance and drug product capacity.
Lead demand reviews with each partner, challenge forecast assumptions, and ensure forecast quality meets defined accuracy and bias targets.

Clinical & Commercial Supply Execution

Support and communicate the end-to-end order-to-delivery process for clinical through commercial supply shipments to partners, including order confirmation, release coordination, customs documentation, and on-time delivery.