Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a dynamic, patient-centric, strategic, collaborative, agile, and results-oriented Executive Business Director (EBD), Epilepsy to lead our West region. This leader will be responsible for leading and developing a team of Regional Sales Managers and ensuring successful execution of Xenon's commercial strategy across a multi-state geography. Reporting to the Vice President, Sales, the ABD serves as the senior field leader within the assigned area and is accountable for launch readiness, business performance, leadership development, field effectiveness, and cross-functional execution.

As Xenon prepares for its first commercial launch, the ABD will play a critical role in building the field organization, developing frontline leadership capabilities, establishing performance expectations, and ensuring consistent execution across all regions. The ABD serves as the key link between national commercial strategy and field execution, translating corporate priorities into actionable plans while fostering collaboration across the field and cross-functional partners.

Success in this role requires exceptional leadership, launch expertise, strategic business acumen, strong cross-functional influence, and the ability to build and scale high-performing teams in a dynamic and evolving commercial environment.

This position reports to the VP, Sales and will be fully remote.

RESPONSIBILITIES

Leadership of Leaders

Build and maintain a high-performing team of Regional Sales Managers.

Establish consistent leadership expectations, performance standards, coaching practices, and operating rhythms across the area.

Coach and develop Regional Sales Managers in leadership effectiveness, business planning, strategic account management, and organizational leadership.

Ensure Regional Sales Managers effectively recruit, onboard, develop, and retain high-performing field teams.

Conduct talent reviews, succession planning, development discussions, and performance management activities.